Antimicrobial peptides provide wider coverage for targeting drug‐resistant bacterial pathogens

We need new treatment options to control bacterial infections. Bacteria use several strategies resist drug treatment, including modification of the target, and adaptation a different lifestyle, such as intracellular niches within host cells. Drugs that act on diverse targets are less likely induce resistance in bacteria, than current antibiotics acting single molecular target. Antimicrobial peptides have been explored class because they selectively kill bacteria via mechanism involves recognition negatively charged microbial surface. Furthermore, antimicrobial with cell-penetrating properties can cross cell membranes target cytosol or sequestered vesicles. Therefore, capable evading likelihood establishing is further reduced. This review highlights potential alternative therapeutics pathogens both extracellular environments, avoid acquired drug-resistance.